Recipient of the 2007 Golden Globe Award for Best Drama Television Series and multiple Emmy nominations, including Outstanding Drama Series for the past two years, "Grey's Anatomy" returns to the ABC Television Network for its fifth season.
　　Is "happily ever after" possible for Meredith Grey and Derek "McDreamy" Shepherd? With Meredith experiencing a breakthrough in therapy - the realization that she and Derek can be extraordinary together, rather than ordinary apart -- she and Derek now face the highs and lows of being a committed couple.
　　Continuing their first year as residents at Seattle Grace Hospital, Meredith, Cristina Yang, Izzie Stevens and Alex Karev have interns of their own to mentor, including Meredith's half-sister, Lexie Grey. Lexie has become a roommate and confidante to George O'Malley, who, after divorce with Callie, a breakup with Izzie, and learning that he failed his residency test by only one point, is striving to get both his professional and personal life back on track.
　　After attending to his girlfriend Rebecca's mental illness on his own, and revealing that he had gone through this with his own mother, Alex finds solace in Izzie's arms. Alex must continue through this difficult time, whether or not Izzie remains by his side.
　　Cristina, having finally won out over her tough-as-nails mentor, Erica, is back on track as a surgeon - but is there a chance for new love in her life as well?
　　With the encouragement of Mark "McSteamy" Sloan, Dr. Callie Torres has taken a chance on love with cardiothoracic surgeon, Erica Hahn; now, she and Erica must figure out what happens after the first kiss.
　　Overseeing the residents is the no-nonsense Chief Resident, Miranda Bailey. Facing marital troubles and the difficulty of balancing her work and personal life, Bailey has handed her responsibilities as head of the free clinic over to Izzie. Also striving for balance is Chief of Surgery, Richard Webber, who has reunited with his estranged wife, Adele.
　　The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis - it's in one another that they find comfort, friendship and love. Together they're discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.
　　"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, and Brooke Smith as Erica Hahn.

　　志颖（郑嘉颖 饰）是个家庭背景复杂的香港青年，因为自幼丧母，父亲酗酒，他表现得非常不羁，好像没有了人生目标。而加恩（周丽淇 饰）则是纯洁的女生，未试过恋爱滋味，却对之憧憬向往。加恩与志颖的结识，是因着一个小误会。但很快加恩就发现，自己好像爱上了面前这个显得有点坏坏的男生。一次加恩遇上了被人追打的志颖，把其救回他的家中加以照料，自此友谊渐深。
　　经历了段段波折，志颖和加恩与另外一对友人一起，在许愿树下结成情侣。加恩也渐渐得知志颖身后的秘密，感谢他因为自己而努力改变，没有理会旁人对志颖的偏见。然而，误会却总爱缠绕热恋中的人。志颖被指加害前女友，并贪走了她户口的一大笔钱。志颖被困在迷局里，别人都更认定他本质不良，而此时加恩决定将此事弄个水落石出，看自己是不是爱错了人。

　　叶向晴（佘诗曼 饰）本是含着金汤匙出生的千金小姐，却因为父亲的去世而失去了所有，于是，她和哥哥向阳（麦长青 饰）不得不自食其力，靠经营粥艇维持生计。某日，叶向晴遇见了名为潘卓华（黄浩然 饰）的男子，后者的英俊和善良吸引叶向晴坠入了情网，然而，叶向晴和潘卓华之间的身份和地位差异巨大，两人的恋情遭到了潘卓华家人的强烈反对。
　　最终，潘卓华按照父母之命同门当户对的方宝琦（李诗韵 饰）结为夫妻，然而，他的心中却依然留存着对于叶向晴的爱恋。巧合的是，方宝琦对于自己的婚姻亦十分不满，因为她真正爱着的是小混混关浩长（萧正楠 饰）。

　　这一季中，主修心理学的大学教授Eli（杰米·肯尼迪 Jamie Kennedy 饰）在遭遇一次火灾意外死后复生，竟然成为了能听见亡魂说话的倾听者。在话唠加神经质的Rick去了远方以后，他就成了Melinda（詹妮弗·洛芙·休伊特 Jennifer Love Hewitt 饰）的新助手，一直协助她完成逝者身前的遗愿。Melinda和丈夫Jim（大卫·康拉德 David Conrad 饰）一直努力想生个宝宝，但始终未能如愿。一次在Melinda帮助鬼魂时发生了意外，为救妻子Jim中枪身亡，也变成了游荡的鬼魂。在一次交通事故现场，Jim附身在一个刚死去的人Sam身上复活了，但却失去自己的记忆。
　　Melinda和Jim的爱情能在Sam身上延续吗？那些影子会不会威胁到他们的新生活？

　　悲惨的童年经历让女孩碧雅（Kanya Leenuttapong 饰）早早就失去了父母，过着同外婆相依为命的生活。尽管过着穷困潦倒的日子，但是碧雅的心中依然保留着一片纯净的天空。蒙泰（纳瓦·君拉纳拉 Nawat Kulrattanarak 饰）是含着金汤匙诞生的富家少爷，虽然从小就过着锦衣玉食的生活，但母亲对蒙泰的苛刻管教令他感到十分的不快乐。
　　母亲早早就为蒙泰定下了门当户对的亲事，对方是娇蛮千金大小姐薇雅（Panward Hammanee 饰）。一次偶然中，碧雅因为采摘无忧花而遭到了薇雅的无情打骂，就在此时，蒙泰出现救下了碧雅。之后，机缘巧合之下碧雅成为了薇雅家里的女佣，随着时间的推移，她和蒙泰之间逐渐产生了感情。

　　少林五枚师太座下俗家女弟子李小环与苗翠花，武艺高强，对江湖人间不平之事横眉冷对。不到两年，以“夺命花环”之称几乎横扫广东无敌手，为富不仁鱼肉乡邻者闻之丧胆。
　　两师姐妹遇上了狂妄不羁的方德；方德冷峻英爽，专爱抱打人间不平之能事。此时江湖上正值耀武堂势力强大，横行民间，堂主陆东堂更是滥杀无辜。于是三人联手对付耀武堂……
　　耀武堂终于瓦解，江湖获得片刻宁静；但以杜丽娘为首的一股新势力再令江湖风云再起……
　　在三人联手对敌中，方德喜欢上了苗翠花，可苗翠花看不上方德，但李小环却从内心钟情方德。适逢方德的妻子离家出走，在五枚师太、苗显等人撮合下，方德与苗翠花结为夫妻。李小环怅然若失，嫁给对自己一往情深的雷老虎，并远走他乡。
　　十八年后，小环夫妇带着儿子雷人凤回到广东，却不料与苗翠花之子世玉结怨；擂台上，世玉将人凤脚筋挑断；老虎怒不可遏，上擂台挑战世玉，却反死在世玉手上！两姐妹反目成仇，“夺命花环”终在武台上会面，决一生死……

　　中文系教授秦越经不起法律系老师叶天锦的狂热追求，与原配妻子同系老师韩茹素离婚，与叶天锦再婚。秦越抱着浪漫理想开始了再婚生活，可是日子却一天天平静下来，从前的生活习惯开始固执的打扰着他……

　　《灵异妙探》第三季继续半搞笑路线，在上季结尾的一声“妈”后，Shawn将在新的一季中面对怎样的案件，处理什么样的父母关系呢？
　　在本季中，一直以为是老爸不对的Shawn或许会了解到一件出乎意料的事实，他能否克服儿时的阴影，父子关系又会向什么方向发展呢？Shawn的老爸，到底会不会 继续他的“找伴儿”行动？或是与再次出现的前妻再续前情？
　　哦，当然，还请继续跟随Shawn和Gus踏上探案之旅，他出类拔萃的观察能力以及妙语连珠的性格，保准让你继续又骂又爱，虽然Shawn并非通灵师，但他却是位真正的侦探。