Colonel Branson (Thomas Gibson), head of a secret and covert division of the NSA, keeps the Shadow Wolves operating albeit now independent and rogue. His anger after his daughter was killed in Afghanistan training civilians drives him to defend "his" America and her borders by all means legal or otherwise. When ISIS terrorists begin to sneak across the US Border into Arizona, Branson alerts the Shadow Wolves to track and stop them. Branson sends Eric Shaw (Cody Walker), his most deadly and effective agent, to join up with the Shadow Wolves. The Wolves are led by Nabahe (Graham Greene), a Navajo honored military veteran, and an old colleague of Branson's. At the same time in London Lady Milton-Simon (Louise Lombard), head of an MI6 anti-terrorist division, sends out her elite agent, Major McLaren (Tom Hutch), to track a terrorist named Khan (Solomon Shiv) who has a personal vendetta against the US and the Shadow Wolves. Lady Milton and McLaren learn Khan is heading to Mexico to be ...

　　冷艳飒爽的艾娃（杰西卡·查斯坦 Jessica Chastain 饰）出身名校，曾效力军队，她学业优秀，并且服役期间表现出众，可是情绪方面的不稳定又使她的人生之路充满波折。在过去的许多年里，艾娃受雇于一个神秘的杀手组织，她手法干练，冷峻无情，许多知名政经人士都成了她的枪下鬼。然而艾娃却又一再违反规定，询问刺杀目标被杀的原因，甚至因此导致行动出现意外。她的行为让管理层负责人西蒙（科林·法瑞尔 Colin Farrell 饰）大为光火，所幸一直以来如父如师的联络人杜克（约翰·马尔科维奇 John Malkovich 饰）护她周全。
　　直到某天，西蒙终于无法忍受艾娃的随性，他决定绕过杜克，清除掉这个不稳定的因素……