吸血鬼剧集《血族》由吉尔莫·德尔·托罗（Guillermo del Toro）、卡尔顿·库斯（Carlton Cuse）和查克·霍根（Chuck Hogan）联合打造，该剧改编自同名吸血鬼小说三部曲。 第四季剧情讲述在9个月后，因为核弹爆炸而引起的核冬天遮掩了太阳，令到陷入长期黑暗的世界受没了活动限制的血族所控制，并让血祖建立了一个极权主义的政权。 在这政权下，血祖及它的手下与恐惧的民众形成一种不可靠的关系，人类现在得为血族工作，要是不合作，等待他们的就是死亡。
美国政府制定一项计划，拟花费七十亿美元，建造一台可以提供时空旅行的机器。一位参议员被国会派去检查该项目进展情况，以决定政府是否继续资助这计划。由于项目的进展令议员很失望，因而项目负责人之一托尼决定以身涉险，使用“时光隧道”进行了一次短途的时光履行，回到了过去，以证明该装置的效能。
欢迎来医院值夜班，但必须警告你：你每天都要同时面对拯救生命的考验和运营一家医院的黑暗真相。如果把这两件事情加在一起，你大概就不会认为这是一份可以展现“英勇之举”的好差事了。在圣安东尼奥纪念医院，值午夜班和凌晨班的人通常是一群“特殊品种”——特别是容易兴奋的T.C. Callahan（Eoin Macken）。他曾是个军医，去过残酷的中东战场。但是他很快就会发现一个事实：最艰难的战斗并非发生在战场上，而是在一所真正的医院里，在自己的家中。
一名男子在头部受到撞击后醒来，却发现自己不仅身处1927 年，还跟臭名昭著的强盗头子长得一模一样，于是决定好好利用这个机会。
西西里检察官尼诺·斯科特拉罗 (Nino Scotellaro) 毕生致力于打击黑手党，却突然被指控为黑手党成员。被定罪后，尼诺变得一无所有，并决定实施权谋报复计划。
内详
Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.
The team is back and ready to tackle more of Amsterdam’s criminal underworld.
