20世纪末，一种神秘病毒在世界蔓延，感染者莫不血尽身亡。 热爱摇滚乐的远藤贤知（唐泽寿明 饰）经历过叛逆时期，如今年奔三十的他窝在家乡大阪经营一家连锁超市，上层负责人责骂，母亲聒噪，姐姐的孩子神乃哭泣，贤知小心应付，手忙脚乱。在小学同学聚会上，贤知重逢当年好友义常（香川照之 饰）、青蛙仔（宮迫博之 饰）、丸夫（石塚英彦 饰）、福平（佐佐木藏之介）、阿门（宇梶剛士 饰）等人。从他们口中得知，如今社会上正时兴一个神秘的宗教组织，组织领袖自称“朋友”，而近期发生的一些列恐怖事件皆来自贤知众人童年时杜撰的一本“预言之书”。 不久，童年时的好友当机（生濑胜久 饰）自杀身亡，他在死前几天曾寄给贤知一封信，信中提到秘密基地的标志。为弄清真相，贤知和朋友们挖出当年埋在树下的铁盒，找出那本“预言之书”。他们发现，儿时胡编乱造写下的情节正在一一应验。那位“朋友”似乎就是当年这群孩子中的一员，而他的目的究竟是什么呢？ （影片简介中涉及的人名均以原著漫画中文版翻译为准）
After seventeen years in prison, the former respected Parisian banker Paul Lavond flees with his friend, the lunatic scientist Marcel that is researching with his wife Malita the miniaturization of animals and human beings to improve the resources of mankind. Paul Lavond was framed for robbery by his scoundrel associates Emil Coulvet, Charles Matin and Victor Radin that had stolen his business while his family was doomed to shame, poverty and tragedy. When Marcel reduces the retarded servant Lachna, he learns that the woman is motionless and only responds to the control of his brain and has a heart attack. After the death of Marcel, Paul Lavond sees the chance to use the miniaturization process as instrument of vengeance and he travels to Paris with the insane Malita disguised of Madame Mandilip, a nice old lady and owner of a dolls store. Paul Lavond, using the identity of Madame Mandilip, befriends his resented and estranged daughter Lorraine Lavond and plots a scheme to revenge and vindicate his family name.
